The prion hypothesis in Parkinson's disease: Braak to the future
Identifieur interne : 000C42 ( Main/Exploration ); précédent : 000C41; suivant : 000C43The prion hypothesis in Parkinson's disease: Braak to the future
Auteurs : Naomi P. Visanji [Canada] ; Patricia L. Brooks [Canada] ; Lili-Naz Hazrati [Canada] ; Anthony E. Lang [Canada]Source :
- Acta Neuropathologica Communications [ 2051-5960 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Prions.
- etiology : Parkinson Disease.
- pathology : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Animals, Humans, Models, Neurological, Severity of Illness Index.
Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disorder typified by the presence of intraneuronal inclusions containing aggregated alpha synuclein (αsyn). The progression of parkinsonian pathology and clinical phenotype has been broadly demonstrated to follow a specific pattern, most notably described by Braak and colleagues. In more recent times it has been hypothesized that αsyn itself may be a critical factor in mediating transmission of disease pathology from one brain area to another. Here we investigate the growing body of evidence demonstrating the ability of αsyn to spread transcellularly and induce pathological aggregation affecting neurons by permissive templating and provide a critical analysis of some irregularities in the hypothesis that the progression of PD pathology may be mediated by such a prion-like process. Finally we discuss some key questions that remain unanswered which are vital to determining the potential contribution of a prion-like process to the pathogenesis of PD.
Url:
DOI: 10.1186/2051-5960-1-2
PubMed: 24252164
PubMed Central: 3776210
Affiliations:
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Visanji</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Patient Based Clinical Research, Toronto Western Research Institute, and the Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, McLaughlin Pavilion, 7th Floor Rm 7-403, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Patient Based Clinical Research, Toronto Western Research Institute, and the Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, McLaughlin Pavilion, 7th Floor Rm 7-403, 399 Bathurst Street, Toronto, Ontario M5T 2S8</wicri:regionArea><wicri:noRegion>Ontario M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Brooks, Patricia L" sort="Brooks, Patricia L" uniqKey="Brooks P" first="Patricia L" last="Brooks">Patricia L. Brooks</name><affiliation wicri:level="4"><nlm:aff id="I2">Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queens Park Crescent West, Toronto, Ontario M5S 3H2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queens Park Crescent West, Toronto, Ontario M5S 3H2</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Hazrati, Lili Naz" sort="Hazrati, Lili Naz" uniqKey="Hazrati L" first="Lili-Naz" last="Hazrati">Lili-Naz Hazrati</name><affiliation wicri:level="4"><nlm:aff id="I2">Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queens Park Crescent West, Toronto, Ontario M5S 3H2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queens Park Crescent West, Toronto, Ontario M5S 3H2</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Patient Based Clinical Research, Toronto Western Research Institute, and the Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, McLaughlin Pavilion, 7th Floor Rm 7-403, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Patient Based Clinical Research, Toronto Western Research Institute, and the Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, McLaughlin Pavilion, 7th Floor Rm 7-403, 399 Bathurst Street, Toronto, Ontario M5T 2S8</wicri:regionArea><wicri:noRegion>Ontario M5T 2S8</wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta Neuropathologica Communications</title><idno type="eISSN">2051-5960</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Models, Neurological</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Prions (physiology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Prions</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Models, Neurological</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder typified by the presence of intraneuronal inclusions containing aggregated alpha synuclein (αsyn). The progression of parkinsonian pathology and clinical phenotype has been broadly demonstrated to follow a specific pattern, most notably described by Braak and colleagues. In more recent times it has been hypothesized that αsyn itself may be a critical factor in mediating transmission of disease pathology from one brain area to another. Here we investigate the growing body of evidence demonstrating the ability of αsyn to spread transcellularly and induce pathological aggregation affecting neurons by permissive templating and provide a critical analysis of some irregularities in the hypothesis that the progression of PD pathology may be mediated by such a prion-like process. Finally we discuss some key questions that remain unanswered which are vital to determining the potential contribution of a prion-like process to the pathogenesis of PD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name></author><author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name></author><author><name sortKey="De Vos, Rai" uniqKey="De Vos R">RAI de Vos</name></author><author><name sortKey="Steur, E" uniqKey="Steur E">E Steur</name></author><author><name sortKey="Braak, E" uniqKey="Braak E">E Braak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name></author><author><name sortKey="Jansen Steur, En" uniqKey="Jansen Steur E">EN Jansen 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Sugeno</name></author><author><name sortKey="Kikuchi, A" uniqKey="Kikuchi A">A Kikuchi</name></author><author><name sortKey="Fiesel, Fc" uniqKey="Fiesel F">FC Fiesel</name></author><author><name sortKey="Sasaki, T" uniqKey="Sasaki T">T Sasaki</name></author><author><name sortKey="Aoki, M" uniqKey="Aoki M">M Aoki</name></author><author><name sortKey="Itoyama, Y" uniqKey="Itoyama Y">Y Itoyama</name></author><author><name sortKey="Takeda, A" uniqKey="Takeda A">A Takeda</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Visanji, Naomi P" sort="Visanji, Naomi P" uniqKey="Visanji N" first="Naomi P" last="Visanji">Naomi P. Visanji</name></noRegion><name sortKey="Brooks, Patricia L" sort="Brooks, Patricia L" uniqKey="Brooks P" first="Patricia L" last="Brooks">Patricia L. Brooks</name><name sortKey="Hazrati, Lili Naz" sort="Hazrati, Lili Naz" uniqKey="Hazrati L" first="Lili-Naz" last="Hazrati">Lili-Naz Hazrati</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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